Mechanism of Action

Cathflo® Activase® (alteplase) addresses the root cause of thrombotic occlusions

  • Binds to fibrin in the thrombus, converting entrapped plasminogen to plasma, and initiating local fibrinolysis 8
  • Differs from heparin, an anti-coagulant that inhibits blood clotting 7


  • When Cathflo 2 mg is administered according to the instructions for dosing and administration, circulating plasma levels of alteplase are not expected to reach pharmacologic concentrations


  1. Recombinant tissue plasminogen activator (alteplase) binds to fibrin in thrombus 
  2. Entrapped plasminogen is converted to plasmin by the plasminogen activator (alteplase)
  3. Plasmin conversion initiates local fibrinolysis.

aThe clinical significance of fibrin specificity is unknown.

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The Oncology Nursing Society (ONS) Access Device Standards of Practice recommends the use of 2 mg alteplase (Cathflo Activase) to restore patency and maintain catheter function. 3