Cathflo® Activase® (alteplase) Administration

Allow appropriate Cathflo dwell time before assessing catheter function

Review these general guidelines for administering Cathflo 8

Cathflo Administration

After WASHING hands and applying gloves 8:

1. After reconstitution using 2.2 mL sterile water for injection and aseptic technique, INSPECT solution for foreign matter and discoloration.



2. INSTILL the appropriate dose of Cathflo into the occluded catheter using a 10-mL syringe (see dosing chart).



3. After 30 minutes of DWELL time, assess the catheter function by attempting to aspirate blood. If the catheter is functional, go to the last step; if not functional, go to the next step.



4. ASSESS catheter function after a total of 120 minutes of dwell time by attempting to aspirate blood. If catheter is functional, go to the next step. If catheter is still occluded, a second dose of equal amount may be instilled. Repeat reconstitution and administration steps.



5. If catheter function has been restored, ASPIRATE 4 to 5 mL of blood in patients ≥10 kg or 3 mL in patients <10 kg to remove Cathflo and residual clot. Then discard aspirate and flush the catheter with 0.9% Sodium Chloride, USP. Any unused solution should be discarded.


The INS Infusion Therapy Standards of Practice state that the instillation of alteplase (Cathflo Activase) is safe and effective in restoring catheter patency in patients. 2